Annually 9.6 Million individuals die of cancer globally and more than half of them in the age of 30-80 years. Now, Proton therapy is used to treat many different of cancers and is mainly appropriate in situations where treatment options are conventional or restricted radiotherapy poses a peril to the patient.
Cancer is the second leading cause of death, behind heart disease. The most common cause of cancer in men is prostate cancer, but the most common cause of cancer death in men is lung cancer.
In women, the most common cause of cancer is breast cancer, and like men, the most common cause of cancer death is lung cancer.
The clinical advantages of proton therapy in variance to conventional radiation therapy are extensive, with more than 75,000 patients treated worldwide.
Proton Beam therapy is one of the major forms of radiation therapy in the world. It uses high-power proton beam for cancer treatment. It gives the targeted treatment and expansion unlike any other radiation therapy.
Conventional radiotherapy spend high energy x-ray for the treatment of cancer and convinced benign tumors. It also destroy the surrounding healthy tissue by delivering the radiation to the healthy tissue over tumor. In comparison, Proton beam delivers a high dosage of radiation particularly to the tumor maximizing the chance of cure and turn minimizing the adverse effects to the enclosing healthy tissue.
In other, a superlative advantage is the proper dose distribution. A low dosage of radiation is emanated at the body surface which is followed by a sharp burst once it destroy the tumor, with negligible radiation travelling away from the target.
Conventional radiation Vs Proton Therapy
Conventional radiation is extremely penetrating and delivers a dose throughout any volume of tissue exposed to radiation. However, majority of the radiation is delivered only 0.5 to 3 cm from the patient’s skin, depending on the energy it absolutely was primarily given. It then slowly loses this energy till it reaches the target. As tumors nearly always situated at a depth, conventional radiation actively interacts with outer healthy cells and transfers only small remaining dose of radiation on the deeper diseased cells.
Conversely, the proton could be a significant and charged particle that in time loses its speed because it interacts with human tissue. It’s simply controlled and delivers its utmost dose at an correct depth, that is set by the quantity of energy it absolutely was given by the cyclotron, and reaches as far 32 cm. The proton is credibly fast once it penetrates the patient’s body and deposits particularly a diminutive dose on its approach. The absorbed dose will increase terribly bit by bit with higher depth and lower speed, speedily rising to a peak once the nucleon is finally stopped. The behavior of the nucleon may be specifically determined. Proton therapy aims to focus on tumors within the body, accurately localize the radiation indefinite quantity and spare the patient’s healthy cells, presenting a way less invasive option to treat cancer.
Proton Beam therapy has reworked the treatment of numerous cancers such as skull base tumors, brain tumors, pediatric cancer, breast cancer, prostate cancer, and lung cancer. In cases where treatment choices restricted and Conventional radiotherapy a dangers to patients. Proton beam therapy should a larger extent, trounced the boundaries of conventional radiotherapy.
How does Proton Therapy works
Protons are accelerated in a machine called the cyclotron which results in the particles becoming highly energized. Protons carry a charge and mass that is typically higher than photons used in conventional radiology.
The beam then enters the treatment room via the gantry. The 360-degree revolving gantry facilitates delivery from any angle; enabling the proton beams to reach the most complex and hard to access tumors.
The protons reach the targeted area and slow down sufficiently to release a burst of energy. State-of-the-art Pencil Beam Scanning delivers the radiation dosage pixel by pixel, ensuring peak precision.
Minimum side effects
In proton therapy, the velocity of the protons is regulated to ensure the burst occurs at the precise site of the tumor, minimizing damage to healthy tissue around it. This results in minimal side effects, faster recovery and a better quality of life.
Benefits of Proton Therapy
- Little to no radiation behind the tumor
- Significantly smaller integral dose per treatment
- Proven credentials in reducing risk of side effects
- Better quality of life during and after treatment
- A painless and non-invasive procedure
Proton Prowess ideal for a wide range of Cancers
The treatment of brain tumors is a complicated process, as they are located near vital structures – hormonal, sensory and neurological centers – where damage can result in serious adverse effects such as neurocognitive, hormonal & auditory disorders.
This is why proton therapy, with revolutionary delivery modes like Pencil Beam Scanning is the clear leader to treat CNS cancers. Proton therapy has globally proven to
- Reduce the dose of radiation by 60% to surrounding structures such as the hippo campus, cochlea and pituitary.
- Reduce the incidence of second cancers by 50%.
Skull Base Tumors
Proton therapy is an ideal modality for treating skull base and cervical spine tumors such as chordoma and chondrosarcoma. The dose can be focused in the target, while achieving significant sparing of the brain, brain stem, cervical cord, and optic nerves and chiasm. Proton therapy is recommended for skull base tumors. The benefits on using IMPT are
- Dose escalation possible with proton therapy, between 70-74 GyRBE
- 7-year local control for chordoma and chondrosarcoma are 71% and 94% respectively.
- For cervical spine tumors, 10-year local control rates for chordomas and chondrosarcomas are 54% and 48% respectively
In conventional radiation there was no effective way to treat hepatocellular carcinoma, pancreatic disease and carcinoma of the oesophagus as well as surgery.
Using conventional radiotherapy, there is high risk of damaging the liver, kidney, spinal cord, intestines and lungs. Comparing to conventional radiotherapy, proton therapy offer the following benefits:
- Reduces side effect
- Potentially reduces radiation exposure to close organs by 60%
Head & Neck and Eye Tumors
The use of conventional radiotherapy in the case of these delicate tumors is once again associated with adverse effects such as functional disorders of the salivary glands, or in the case of eyes, a worsened quality of vision.Proton Therapy is ideal treatment mode because : Preserves swallowing functions and sense of taste.
Many treatments for prostate cancer often cause long-term side effects, including urinary complications and impotence. With these serious risks in mind, the precision and power of proton therapy is always recommended for prostate cancer. The benefits include:
- Reduced irradiation of the bladder by 60% thus reducing the risk of incontinence
- Reduce the incidence of second cancers by 50%.
In the case of Lung carcinoma, the precise nature of proton therapy allows a higher dose of radiation to be delivered directly to where it needs to be – the tumor. In addition, the treatment time is shortened, and healthy lung tissue is preserved. Proton therapy has emerged superior to conventional radiation in treating Lung Cancer for the following benefit:
Lowers radiation exposure to surrounding structures by 50%
Both standard radiation therapy and proton therapy work on the same principle of damaging cellular DNA. The major advantage of proton therapy treatment over standard radiation therapy, however, is that protons slowly deposit their energy as they travel towards the cancerous tumor and then due to a unique physical characteristic called the Bragg Peak, deposit the majority of the radiation dose directly in the tumor and travel no further through the body. This results in less healthy tissues and organs receiving unnecessary radiation thereby reducing unwanted complications and side effects. Standard radiation therapy utilizes x-rays which deposits the majority of the radiation dose immediately upon entering the body while traveling to the tumor. Unlike protons, after depositing radiation dose in the tumor the x-rays continue traveling through the body until exiting out the other side resulting in the delivery of unnecessary radiation to healthy tissues and organs. Simply put, protons STOP after depositing the radiation dose in the tumor, x-rays do not.
These unique advantages of proton therapy lead to the potential for fewer harmful side effects, more direct impact on the tumor, and increased tumor control.
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