MULTI ORGAN TRANSPLANT

Experts performing multiorgan transplant procedures, including heart-lung, heart-liver, heart-kidney, kidney-pancreas, liver-kidney and heart-lung-liver transplants. Surgeons use innovative techniques in multiorgan transplant surgery and other types of transplant surgery, with excellent results. Surgeons also perform multiorgan transplant procedures in children. Doctors trained in many areas work together as a team in the Transplant Center to treat people who need multiorgan transplants.

Kidney Transplant

Kidney transplantation means replacement of the failed kidneys with a working kidney from another person, called a donor. Many people who receive a kidney transplant are able to live much as they did before their kidneys failed. People who receive a transplant must take medication and be monitored by a physician who specializes in kidney disease (nephrologist) for the rest of their lives.

When you get a kidney transplant, a healthy kidney is placed inside your body to do the work your own kidneys can no longer do.

On the plus side, there are fewer limits on what you can eat and drink, but you should follow a heart-healthy diet. Your health and energy should improve. In fact, a successful kidney transplant may allow you to live the kind of life you were living before you got kidney disease. Studies show that people with kidney transplants live longer than those who remain on dialysis.

On the minus side, there are the risks of surgery. You will also need to take anti-rejection medicines for as long as your new kidney is working, which can have side effects. You will have a higher risk for infections and certain types of cancer.

Although most transplants are successful and last for many years, how long they last can vary from one person to the next. Many people will need more than one kidney transplant during a lifetime.

Liver Transplant

A liver transplant is a surgical procedure to remove a diseased liver and replace it with a healthy liver from a donor. Most liver transplant operations use livers from deceased donors, though a liver may also come from a living donor. The donor liver is transported in a cooled salt-water (saline) solution that preserves the organ for up to 8 hours. The necessary tests can then be done to match the donor with the recipient. The new liver is removed from the donor through a surgical cut in the upper abdomen. It is placed into the patient who needs the liver (called the recipient), and attached to the blood vessels and bile ducts. The operation may take up to 12 hours. The recipient will often need a large amount of blood through a transfusion.

The most common reason for a liver transplant in adults is cirrhosis. Cirrhosis is scarring of the liver that prevents the liver from working well. It can worsen to liver failure. The most common causes of cirrhosis are:

  • Long-term infection with hepatitis B or hepatitis C
  • Long-term alcohol abuse (See: Alcoholic liver disease)

Other illnesses that may cause cirrhosis and liver failure include:

Autoimmune Hepatitis

  • Hepatic vein blood clot (thrombosis)
  • Liver damage from poisoning or medications
  • Problems with the drainage system of the liver (the biliary tract), such as primary biliary cirrhosis or primary sclerosing cholangitis
  • Metabolic disorders of copper or iron (Wilson’s disease and hemochromatosis)

Liver Transplant Preparation

Before you undergo liver transplant, we require relevant records of the patient as instructed by our doctors. Once the doctor has checked and approved that you can undergo liver transplant, the next step is to arrange the donor. As per the medical requirements, the donor should a family member between 18 to 65 years old with suitable blood group. There are various tests that the donor and recipients need to go through before leaving the home country for treatment.

CMT helps you right from initial consultation to meetings/discussion with doctors, explaining legal requirements and other important items.

Bone Marrow Transplant

A bone marrow transplant is a procedure to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Bone marrow is the soft, fatty tissue inside your bones. Stem cells are immature cells in the bone marrow that give rise to all of your blood cells.

Your doctor may recommend a bone marrow transplant if you have:

  • Certain cancers, such as leukemia, lymphoma, and multiple myeloma.
  • A disease that affects the production of bone marrow cells, such as aplastic anemia, congenital neutropenia, severe immunodeficiency syndromes, sickle cell anemia, thalassemia.
  • Had chemotherapy that destroyed your bone marrow.

Types of Bone Marrow Transplants

Autologous Bone Marrow Transplant

The term auto means self. In this transplant, a person’s own stem cells are used. This involves harvesting cells before beginning a damaging therapy like chemotherapy or radiation. After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make (regenerate) normal blood cells. This is called a rescue transplant.

Allogeneic Bone Marrow Transplant

The term ‘allo’ means other. In this transplant stem cells from the other person called ‘donor’ is used. A compatible relative is normally preferred but genetic matches can also be found from a donor registry. Allogeneic transplants is prescribed if you have a condition that has damaged your bone marrow cells. However, they have a higher risk of certain complications, such as graft-versus-host disease. The success of an allogeneic transplant depends on how closely the donor cells match your own stem cells.

Umbilical Cord Blood Transplant

This is a type of allogeneic transplant. Stem cells are removed from a newborn baby’s umbilical cord right after birth. The stem cells are frozen and stored until they are needed for a transplant. Umbilical cord blood cells are very immature so there is less of a need for matching. But blood counts take longer to recover.

A stem cell transplant is done after chemotherapy and radiation is complete. The stem cells are delivered into your bloodstream usually through a tube called a central venous catheter. The process is similar to getting a blood transfusion. The stem cells travel through the blood into the bone marrow. Most times, no surgery is needed.

A stem cell transplant is done after chemotherapy and radiation is complete. The stem cells are delivered into your bloodstream usually through a tube called a central venous catheter. The process is similar to getting a blood transfusion. The stem cells travel through the blood into the bone marrow. Most times, no surgery is needed.

Corneal Transplant

If your cornea no longer lets light enter your eye properly because of scarring or disease, you may need a transplant. Your doctor will call it a keratoplasty. During the procedure, an eye surgeon removes a portion of the cornea and replaces it with a new section from a donor.

This clear tissue covers the front of each eye. Light passes through it to enter your eye, then goes through your pupil (the dark spot at the center of the eye), and then through the lens.

Heart Transplant

Heart transplantation is a relatively simple operation for a cardiac surgeon. In fact, the procedure actually consists of three operations.

The first operation is harvesting the heart from the donor. The donor is usually an unfortunate person who has suffered irreversible brain injury, called “brain death”. Very often these are patients who have had major trauma to the head, for example, in an automobile accident. The victim’s organs, other than the brain, are working well with the help of medications and other “life support” that may include a respirator or other devices. A team of physicians, nurses, and technicians goes to the hospital of the donor to remove donated organs once brain death of the donor has been determined. The removed organs are transported on ice to keep them alive until they can be implanted. For the heart, this is optimally less than six hours. So, the organs are often flown by airplane or helicopter to the recipient’s hospital.

The second operation is removing the recipient’s damaged heart. Removing the damaged heart may be very easy or very difficult, depending on whether the recipient has had previous heart surgery (as is often the case). If there has been previous surgery, cutting through the scar tissue may prolong and complicate removal of the heart.

The third operation is probably the easiest; the implantation of the donor heart. Today, this operation basically involves the creation of only five lines of stitches, or “anastomoses”. These suture lines connect the large blood vessels entering and leaving the heart. Remarkably, if there are no complications, most patients who have had a heart transplant are home about one week after the surgery. The generosity of donors and their families makes organ transplant possible.

Candidates for Heart Transplant

There are not enough donor hearts available for everyone who may need a hear transplant. Therefore, there is a careful selection process in place to assure that hearts are distributed fairly and to those who will benefit most from the donor heart. The heart is just a pump, although a complicated pump. Most patients require a transplant because their hearts can no longer pump well enough to supply blood with oxygen and nutrients to the organs of the body. A smaller number of patients have a good pump, but a bad “electrical conduction system” of the heart. This electrical system determines the rate, rhythm and sequence of contraction of the heart muscle. There are all kinds of problems that can occur with the conduction system, including complete interruption of cardiac function causing sudden cardiac death.

CMT helps you right from initial consultation to meetings/discussion with doctors, explaining legal requirements and other important terms.